In the subventricular zone (SVZ) new neurons are produced from neural stem cells throughout life.  These new cells, called neuroblasts migrate along a path consisting of blood vessels and GFAP+ astrocytes approximately 5 mm in length called the rostral migratory stream (RMS) to the olfactory bulb. Neuroblasts migrate tangentially through the RMS and then switch to radial migration once in the OB, to their final destination in either the granule layer or glomerular layer, where the neuroblasts differentiate into interneurons. Changes in adult neurogenesis occur with age such that there are fewer neurons produced.  We are interested in further understanding the affects of aging on the processes of adult neurogenesis, migration and differentiation of neuroblasts.